Inheritance of hormonal disorder marked by excessive insulin in daughters Elevated levels of insulin could be an early sign that girls whose mothers suffer from polycystic ovary syndrome — or PCOS — may also be susceptible to the disease, according to gynecologists who have found evidence of insulin resistance in young children. The findings could…
Genetics (Siblings, Parents, Offspring, Ethnicity)
Does PCOS start in childhood?
Pediatr Endocrinol Rev. 2008 Jun;5(4):904-11. Does polycystic ovary syndrome start in childhood? Diamanti-Kandarakis E, Christakou C, Palioura E, Kandaraki E, Livadas S. Division of Endocrinology, First Department of Medicine, Laiko Hospital, Medical School, University of Athens, Athens, Greece. Polycystic Ovary Syndrome (PCOS), the most frequent endocrinopathy in reproductive-aged women, represents a multifactorial nosologic entity considering…
Differences in dyslipidemia between American and Italian women with PCOS
J Endocrinol Invest. 2008 Jan Differences in dyslipidemia between American and Italian women with polycystic ovary syndrome. Essah PA, Nestler JE, Carmina E. Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. BACKGROUND: Dyslipidemia is a common metabolic complication in polycystic ovary syndrome (PCOS). The aim of this study was to…
Brothers of women with PCOS may be at increased risk of cardiovascular disease
J Obstet Gynaecol. 2007 Aug To determine whether first-degree male relatives of women with polycystic ovary syndrome are at higher risk of developing cardiovascular disease and type II diabetes mellitus. Hunter A, Vimplis S, Sharma A, Eid N, Atiomo W. Medical School, University of Nottingham, Nottingham, UK. The aim of this study was to determine…
Hey Cysters, do you have a BROTHER? He may be at risk…
Diabetologia. 2007 Dec Brothers of women with polycystic ovary syndrome are characterised by impaired glucose tolerance, reduced insulin sensitivity and related metabolic defects. Baillargeon JP, Carpentier AC. Division of Endocrinology, Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada. JP.Baillargeon@USherbrooke.ca AIMS/HYPOTHESIS: Since it has been shown that polycystic ovary syndrome (PCOS) is highly inherited and…
Will Metformin Work for you? The Answer May be in your Genes!
Gene Variation Predicts Response to Treatment in Common Infertility Disorder March 27, 2008 NIH-sponsored researchers have discovered that women who have polycystic ovary syndrome (PCOS) are less likely to ovulate in response to a promising new drug treatment for the condition if they have a variation in a particular gene. The gene, known as STK…
Early Signs of PCOS in Daughters of Women with PCOS
J Clin Endocrinol Metab. 2007 Dec; Early metabolic derangements in daughters of women with polycystic ovary syndrome. Sir-Petermann T, Maliqueo M, Codner E, Echiburú B, Crisosto N, Pérez V, Pérez-Bravo F, Cassorla F. Endocrinology and Metabolism Laboratory, University of Chile, Santiago, Chile. tsir@med.uchile.cl CONCLUSIONS: Some of the metabolic features of PCOS are present in daughters…
The Genetic Basis of the Polycystic Ovary Syndrome
The Genetic Basis of the Polycystic Ovary Syndrome: A Literature Review Including Discussion of PPAR-gamma. PPAR Res. 2007 Unluturk U, Harmanci A, Kocaefe C, Yildiz BO. Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Hacettepe, 06100 Ankara, Turkey. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the women of reproductive age….
Looking for polycystic ovary syndrome genes: rational and best strategy
Semin Reprod Med. 2008 Jan;26(1):5-13. Links Looking for polycystic ovary syndrome genes: rational and best strategy. Goodarzi MO. Department of Medicine, David Geffen School of Medicine at UCLA; Division of Endocrinology, Diabetes & Metabolism, Medical Genetics Institute; Center for Androgen Related Disorders, Cedars-Sinai Medical Center, Los Angeles, California. Polycystic ovary syndrome (PCOS) is a common,…
Is PCOS due to Intrafamily Marriages? (aka ‘inbreeding’?)
Gynecol Obstet Invest. 2008 Jan 15;65(4):269-274 Infertility and Polycystic Ovarian Syndrome: A Study of Association between Body Mass Index and Intrafamily Marriages. Haq F, Rizvi J. Department of Obstetrics and Gynecology, Aga Khan University Hospital, Karachi, Pakistan. Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder which causes anovulatory infertility. Obesity is one of…
