Fertil Steril. 2008 Jan 25
Therapeutic response to metformin in an underweight patient with polycystic ovarian syndrome.
Al-Ozairi E, Quinton R, Advani A.
Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
OBJECTIVE: To report a case where insulin sensitization restored menses in an underweight woman with polycystic ovarian syndrome (PCOS).
RESULT(S): Metformin, without weight loss or increased physical activity, resulted in restoration of menstrual cycle, reduction in serum T, and improvement in insulin resistance (IR).
CONCLUSION(S): This case highlights the contribution of PCOS-related IR, distinct from visceral adiposity, and demonstrates the effectiveness of pharmacological insulin-sensitization independent of weight loss or lifestyle adjustments.
DESIGN: Case report.
SETTING: Tertiary care center.
PATIENT(S): A 19-year-old woman with a body mass index of 16.9 kg/m(2), severe hirsutism, and oligomenorrhea.
INTERVENTION(S): Insulin sensitization with metformin.
MAIN OUTCOME MEASURE(S): Impact of metformin therapy on menstrual cycle and serum T and fasting insulin levels.