J Clin Endocrinol Metab. 2006 Jan 31
Relationship of Adolescent Polycystic Ovary Syndrome to Parental Metabolic Syndrome.
Leibel NI, Baumann EE, Kocherginsky M, Rosenfield RL.
Departments of Pediatrics, Medicine, and Health StudiesThe University of Chicago Pritzker School of Medicine, Chicago, IL.
Conclusion. Familial factors related to paternal MBS seem to be fundamental to the pathogenesis of PCOS.
Context. We determined the relationship of metabolic syndrome (MBS) to polycystic ovary syndrome (PCOS).
Objective. We tested the hypothesis that parental MBS is related to the PCOS phenotype in their offspring.
Design/Setting. We phenotyped for MBS and PCOS in our General Clinical Research Center.
Patients. Girls with PCOS, 12-19 yr (n = 36, including 1 pair of siblings) and their parents (35 mothers, 19 fathers) were recruited from the Pediatric Endocrinology Clinic. Healthy girls, 12-19 yr (n = 21), were recruited as a reference population. Interventions. We measured anthropometrics, blood pressure, fasting lipids and androgens, oral glucose tolerance, and ultrasonographically determined polycystic ovary status.
Main Outcome Measures. MBS in parents, and PCOS features in mothers, were related to the presence of PCOS features in probands.
Results. Fathers had strikingly high prevalences of excess adiposity (94% were obese or overweight) and MBS (79%). Premenopausal mothers more commonly had MBS (36%) than features of PCOS (
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