Stress, Obesity and PCOS

Stress, Obesity, and Metabolic Syndrome
Volume 1083 published November 2006
Ann. N.Y. Acad. Sci. 1083: 54–62 (2006). doi: 10.1196/annals.1367.006

Key Words: polycystic ovary syndrome • metabolic syndrome • stress

Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome that is characterized from oligo- or anovulation, clinical and/or biochemical signs of hyperandrogenism, and polycystic ovaries. Clinical expression is determined by genetic as well as environmental factors. Women with PCOS are a specific group of women which have several aspects of metabolic syndrome (MBS). Concomitantly MBS could be part of metabolic abnormalities present in PCOS. Stress has been linked to aggravate the metabolic abnormalities present in MBS. An interaction seems to exist between stress, environmental, as well as genetic factors, starting from the prenatal age and continuing to the adult life. This results in specific endocrinological and metabolic disorders which are shared by women with PCOS and women with MBS.

Address for correspondence: Evanthia Diamanti-Kandarakis, Athens University School of Medicine, Laiko General Hospital, 1A Zefyrou str, Athens 145 78, Greece. e-mail:

Metabolic Syndrome and Polycystic Ovary Syndrome

Endocrine Section of First Department of Internal Medicine, Athens University School of Medicine, Laiko General Hospital, Athens 115 27, Greece